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SMO Antibody (monoclonal) (M10)

Mouse monoclonal antibody raised against a partial recombinant SMO.

  • E - SMO Antibody (monoclonal) (M10) AT3960a
    Detection limit for recombinant GST tagged SMO is approximately 0.3ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99835
Other Accession NM_005631
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 2F12
Calculated MW 86397 Da
Additional Information
Gene ID 6608
Other Names Smoothened homolog, SMO, Protein Gx, SMO, SMOH
Target/Specificity SMO (NP_005622, 56 a.a. ~ 155 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsSMO Antibody (monoclonal) (M10) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex.


Immunohistochemical expression of SHH, PTC, SMO and GLI1 in glandular odontogenic cysts and dentigerous cysts. Zhang L, et al. Oral Dis, 2010 Jun 18. PMID 20561215.Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts. Walter K, et al. Clin Cancer Res, 2010 Mar 15. PMID 20215540.Smoothened as a new therapeutic target for human osteosarcoma. Hirotsu M, et al. Mol Cancer, 2010 Jan 12. PMID 20067614.Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin. Ritti? L, et al. Aging Cell, 2009 Dec. PMID 20050020.The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. Landa I, et al. PLoS Genet, 2009 Sep. PMID 19730683.

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$ 315.00
Cat# AT3960a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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