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SNAI2 Antibody (monoclonal) (M04)

Mouse monoclonal antibody raised against a partial recombinant SNAI2.

     
  • IF - SNAI2 Antibody (monoclonal) (M04) AT3969a
    Immunofluorescence of monoclonal antibody to SNAI2 on HeLa cell. [antibody concentration 10 ug/ml]
    detail
  • WB - SNAI2 Antibody (monoclonal) (M04) AT3969a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (33.77 KDa) .
    detail
  • WB - SNAI2 Antibody (monoclonal) (M04) AT3969a
    SNAI2 monoclonal antibody (M04), clone 4D11 Western Blot analysis of SNAI2 expression in Hela S3 NE ( (Cat # AT3969a )
    detail
  • E - SNAI2 Antibody (monoclonal) (M04) AT3969a
    Detection limit for recombinant GST tagged SNAI2 is 0.3 ng/ml as a capture antibody.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF, E
Primary Accession O43623
Other Accession NM_003068
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 4D11
Calculated MW 29986 Da
Additional Information
Gene ID 6591
Other Names Zinc finger protein SNAI2, Neural crest transcription factor Slug, Protein snail homolog 2, SNAI2, SLUG, SLUGH
Target/Specificity SNAI2 (NP_003059, 97 a.a. ~ 169 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsSNAI2 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects.

References

Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.SNAI2/Slug promotes growth and invasion in human gliomas. Yang HW, et al. BMC Cancer, 2010 Jun 17. PMID 20565806.Clinicopathologic significance of slug expression in human intrahepatic cholangiocarcinoma. Zhang KJ, et al. World J Gastroenterol, 2010 May 28. PMID 20503457.SLUG: a new target of lymphoid enhancer factor-1 in human osteoblasts. Lambertini E, et al. BMC Mol Biol, 2010 Feb 3. PMID 20128911.ERalpha signaling through slug regulates E-cadherin and EMT. Ye Y, et al. Oncogene, 2010 Mar 11. PMID 20101232.

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$ 350.00
Cat# AT3969a
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Availability: 7-10 days
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