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SNCB Antibody (monoclonal) (M07)

Mouse monoclonal antibody raised against a full-length recombinant SNCB.

     
  • WB - SNCB Antibody (monoclonal) (M07) AT3979a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (40.48 KDa) .
    detail
  • WB - SNCB Antibody (monoclonal) (M07) AT3979a
    Western Blot analysis of SNCB expression in transfected 293T cell line by SNCB monoclonal antibody (M07), clone 3H4.

    Lane 1: SNCB transfected lysate(14.3 KDa).
    Lane 2: Non-transfected lysate.
    detail
  • E - SNCB Antibody (monoclonal) (M07) AT3979a
    Detection limit for recombinant GST tagged SNCB is approximately 1ng/ml as a capture antibody.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q16143
Other Accession BC002902
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 3H4
Calculated MW 14288 Da
Additional Information
Gene ID 6620
Other Names Beta-synuclein, SNCB
Target/Specificity SNCB (AAH02902, 1 a.a. ~ 134 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsSNCB Antibody (monoclonal) (M07) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene.

References

Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy body disease. Nishioka K, et al. Arch Neurol, 2010 Aug. PMID 20697047.Expression of alpha-, beta- and gamma-synuclein in colorectal cancer, and potential clinical significance in progression of the disease. Ye Q, et al. Oncol Rep, 2010 Feb. PMID 20043104.Molecular determinants of the aggregation behavior of alpha- and beta-synuclein. Rivers RC, et al. Protein Sci, 2008 May. PMID 18436957.Spectroscopic and functional characterization of human beta-synuclein. Lee J, et al. Protein Pept Lett, 2007. PMID 18221001.An investigation into the lipid-binding properties of alpha-, beta- and gamma-synucleins in human brain and cerebrospinal fluid. Salem SA, et al. Brain Res, 2007 Sep 19. PMID 17692832.

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$ 350.00
Cat# AT3979a
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Availability: 7-10 days
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