SNX1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SNX1.
|Application ||WB, IHC, E|
|Calculated MW||59070 Da|
|Other Names||Sorting nexin-1, SNX1|
|Target/Specificity||SNX1 (NP_003090, 166 a.a. ~ 275 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SNX1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms.
Regulation of P2Y1 receptor traffic by sorting Nexin 1 is retromer independent. Nisar S, et al. Traffic, 2010 Apr. PMID 20070609.SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors. Mari M, et al. Traffic, 2008 Mar. PMID 18088323.EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. Bryant DM, et al. J Cell Sci, 2007 May 15. PMID 17502486.Sorting nexin 1 down-regulation promotes colon tumorigenesis. Nguyen LN, et al. Clin Cancer Res, 2006 Dec 1. PMID 17145813.Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. Rojas R, et al. Mol Cell Biol, 2007 Feb. PMID 17101778.
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