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SOCS6 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a full length recombinant SOCS6.

  • WB - SOCS6 Antibody (monoclonal) (M01) AT3991a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (84.59 KDa) .
  • E - SOCS6 Antibody (monoclonal) (M01) AT3991a
    Detection limit for recombinant GST tagged SOCS6 is approximately 1ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O14544
Other Accession BC020082
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a kappa
Clone Names M2-F12
Calculated MW 59528 Da
Additional Information
Gene ID 9306
Other Names Suppressor of cytokine signaling 6, SOCS-6, Cytokine-inducible SH2 protein 4, CIS-4, Suppressor of cytokine signaling 4, SOCS-4, SOCS6, CIS4, SOCS4
Target/Specificity SOCS6 (AAH20082, 1 a.a. ~ 535 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsSOCS6 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.


Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation. Choi YB, et al. J Biol Chem, 2010 Mar 5. PMID 20007709.Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.Genomic organization and functional characterization of the promoter for the human suppressor of cytokine signaling 6 gene. Lai RH, et al. Gene, 2009 Dec 1. PMID 19716864.

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$ 315.00
Cat# AT3991a
(40 western blots)
Availability: 7-10 days
Bulk Size
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