SORD Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SORD.
|Application ||WB, IHC, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||38325 Da|
|Other Names||Sorbitol dehydrogenase, L-iditol 2-dehydrogenase, SORD|
|Target/Specificity||SORD (NP_003095, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SORD Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Sorbitol dehydrogenase (SORD; EC 220.127.116.11) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.
1.Sorbitol dehydrogenase expression is regulated by androgens in the human prostate.Szabo Z, Hamalainen J, Loikkanen I, Moilanen AM, Hirvikoski P, Vaisanen T, Paavonen TK, Vaarala MH.Oncol Rep. 2010 May;23(5):1233-9.
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