|Application ||WB, IF, E|
|Calculated MW||44994 Da|
|Other Names||Transcription factor Sp7, Zinc finger protein osterix, SP7, OSX|
|Target/Specificity||SP7 (NP_690599, 87 a.a. ~ 162 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SP7 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.
Identification of a frameshift mutation in Osterix in a patient with recessive osteogenesis imperfecta. Lapunzina P, et al. Am J Hum Genet, 2010 Jul 9. PMID 20579626.Replication of previous genome-wide association studies of bone mineral density in premenopausal American women. Ichikawa S, et al. J Bone Miner Res, 2010 Aug. PMID 20200978.Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase. Sinha KM, et al. EMBO J, 2010 Jan 6. PMID 19927124.Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Rivadeneira F, et al. Nat Genet, 2009 Nov. PMID 19801982.High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Yerges LM, et al. J Bone Miner Res, 2009 Dec. PMID 19453261.
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