SPAG5 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SPAG5.
|Calculated MW||134422 Da|
|Other Names||Sperm-associated antigen 5, Astrin, Deepest, Mitotic spindle-associated protein p126, MAP126, SPAG5|
|Target/Specificity||SPAG5 (AAH00322, 1082 a.a. ~ 1191 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SPAG5 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles.
Centrosome-related genes, genetic variation, and risk of breast cancer. Olson JE, et al. Breast Cancer Res Treat, 2010 May 28. PMID 20508983.SNM1B/Apollo interacts with astrin and is required for the prophase cell cycle checkpoint. Liu L, et al. Cell Cycle, 2009 Feb 15. PMID 19197158.Astrin regulates Aurora-A localization. Du J, et al. Biochem Biophys Res Commun, 2008 May 30. PMID 18361916.Glycogen synthase kinase 3beta interacts with and phosphorylates the spindle-associated protein astrin. Cheng TS, et al. J Biol Chem, 2008 Jan 25. PMID 18055457.Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity. Thein KH, et al. J Cell Biol, 2007 Jul 30. PMID 17664331.
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