SPN Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant SPN.
|Application ||WB, E|
|Calculated MW||40322 Da|
|Other Names||Leukosialin, Galactoglycoprotein, GALGP, Leukocyte sialoglycoprotein, Sialophorin, CD43, SPN, CD43|
|Target/Specificity||SPN (AAH12350, 1 a.a. ~ 400 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SPN Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.
Binding of the Streptococcus gordonii DL1 surface protein Hsa to the host cell membrane glycoproteins CD11b, CD43, and CD50. Urano-Tashiro Y, et al. Infect Immun, 2008 Oct. PMID 18678668.The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramembrane proteolysis by presenilin/gamma-secretase. Mambole A, et al. J Biol Chem, 2008 Aug 29. PMID 18586676.The selective expression of CD43 in adenoid cystic carcinoma. Seethala RR, et al. Appl Immunohistochem Mol Morphol, 2008 Mar. PMID 18227725.LFA-1-mediated leukocyte adhesion regulated by interaction of CD43 with LFA-1 and CD147. Khunkaewla P, et al. Mol Immunol, 2008 Mar. PMID 17996943.Site-specific morphologic differences in extranodal marginal zone B-cell lymphomas. Rawal A, et al. Arch Pathol Lab Med, 2007 Nov. PMID 17979485.
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