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STAG1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant STAG1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | Q8WVM7 |
| Other Accession | BC064699 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 2E10 |
| Calculated MW | 144427 Da |
| Gene ID | 10274 |
|---|---|
| Other Names | Cohesin subunit SA-1, SCC3 homolog 1, Stromal antigen 1, STAG1, SA1 |
| Target/Specificity | STAG1 (AAH64699, 1112 a.a. ~ 1221 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | STAG1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase.
References
Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. Chasman DI, et al. PLoS Genet, 2009 Nov. PMID 19936222.Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells. Canudas S, et al. J Cell Biol, 2009 Oct 19. PMID 19822671.CTCF physically links cohesin to chromatin. Rubio ED, et al. Proc Natl Acad Sci U S A, 2008 Jun 17. PMID 18550811.Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Watrin E, et al. Curr Biol, 2006 May 9. PMID 16682347.Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
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