STAM2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant STAM2.
|Application ||WB, IP, E|
|Calculated MW||58164 Da|
|Other Names||Signal transducing adapter molecule 2, STAM-2, Hrs-binding protein, STAM2, HBP|
|Target/Specificity||STAM2 (NP_005834, 416 a.a. ~ 525 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||STAM2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.
PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2. Stuible M, et al. J Biol Chem, 2010 Jul 30. PMID 20504764.An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904.STAM adaptor proteins interact with COPII complexes and function in ER-to-Golgi trafficking. Rismanchi N, et al. Traffic, 2009 Feb. PMID 19054391.E3-independent monoubiquitination of ubiquitin-binding proteins. Hoeller D, et al. Mol Cell, 2007 Jun 22. PMID 17588522.Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation. Kong C, et al. J Biol Chem, 2007 May 18. PMID 17403676.
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