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STAU1 Antibody (monoclonal) (M03)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT4069a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
STAU1 Antibody (monoclonal) (M03) - Product info | |
| Primary Accession | O95793 |
| Other Accession | NP_004593 |
| Reactivity | Human |
| Concentration | 1 mg/ml |
| Isotype | IgG2b Kappa |
| Clone Names | 3C12 |
| Calculated MW | 63182 Da |
STAU1 Antibody (monoclonal) (M03) - Additional info | |
| Gene ID 6780 | |
| Other Names STAUstaufen, RNA binding protein, homolog 1 (Drosophila) | |
| Target/Specificity STAU1 (NP_004593, 401 a.a. ~ 497 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions STAU1 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. | |
STAU1 Antibody (monoclonal) (M03) - Related products
RI15115: STAU1 predesign siRNA
DC07797: Human STAU1 cDNA Clone
STAU1 Antibody (monoclonal) (M03) - Application data
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Detection limit for recombinant GST tagged STAU1 is approximately 0.3ng/ml as a capture antibody.
STAU1 Antibody (monoclonal) (M03) - Research Areas
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BACKGROUND
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR.
REFERENCES
Human Staufen1 protein interacts with influenza virus ribonucleoproteins and is required for efficient virus multiplication. de Lucas S, et al. J Virol, 2010 Aug. PMID 20504931.Live cell visualization of the interactions between HIV-1 Gag and the cellular RNA-binding protein Staufen1. Milev MP, et al. Retrovirology, 2010 May 10. PMID 20459747.Multimerization of Staufen1 in live cells. Martel C, et al. RNA, 2010 Mar. PMID 20075165.Novel Staufen1 ribonucleoproteins prevent formation of stress granules but favour encapsidation of HIV-1 genomic RNA. Abrahamyan LG, et al. J Cell Sci, 2010 Feb 1. PMID 20053637.The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor. Crawford NP, et al. J Biol Chem, 2009 Oct 16. PMID 19710015.
