STCH Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant STCH.
|Application ||WB, IF, E|
|Calculated MW||51927 Da|
|Other Names||Heat shock 70 kDa protein 13, Microsomal stress-70 protein ATPase core, Stress-70 protein chaperone microsome-associated 60 kDa protein, HSPA13, STCH|
|Target/Specificity||STCH (NP_008879.3, 375 a.a. ~ 470 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||STCH Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein.
Chemical manipulation of hsp70 ATPase activity regulates tau stability. Jinwal UK, et al. J Neurosci, 2009 Sep 30. PMID 19793966.New sequence variants associated with bone mineral density. Styrkarsdottir U, et al. Nat Genet, 2009 Jan. PMID 19079262.Stomach cancer-derived del223V-226L mutation of the STCH gene causes loss of sensitization to TRAIL-mediated apoptosis. Yamagata N, et al. Biochem Biophys Res Commun, 2008 Nov 21. PMID 18793616.A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Lim J, et al. Cell, 2006 May 19. PMID 16713569.Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514.
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