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STIP1 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a full length recombinant STIP1.

     
  • IF - STIP1 Antibody (monoclonal) (M01) AT4076a
    Immunofluorescence of monoclonal antibody to STIP1 on HeLa cell. [antibody concentration 10 ug/ml]
    detail
  • IP - STIP1 Antibody (monoclonal) (M01) AT4076a
    Immunoprecipitation of STIP1 transfected lysate using anti-STIP1 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with STIP1 MaxPab rabbit polyclonal antibody.
    detail
  • WB - STIP1 Antibody (monoclonal) (M01) AT4076a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (85.25 KDa) .
    detail
  • WB - STIP1 Antibody (monoclonal) (M01) AT4076a
    STIP1 monoclonal antibody (M01), clone 4B6 Western Blot analysis of STIP1 expression in HeLa ( (Cat # AT4076a )
    detail
  • WB - STIP1 Antibody (monoclonal) (M01) AT4076a
    Western Blot analysis of STIP1 expression in transfected 293T cell line by STIP1 monoclonal antibody (M01), clone 4B6.

    Lane 1: STIP1 transfected lysate(62.6 KDa).
    Lane 2: Non-transfected lysate.
    detail
  • IHC - STIP1 Antibody (monoclonal) (M01) AT4076a
    Immunoperoxidase of monoclonal antibody to STIP1 on formalin-fixed paraffin-embedded human testis. [antibody concentration 0.3 ug/ml]
    detail
  • E - STIP1 Antibody (monoclonal) (M01) AT4076a
    Detection limit for recombinant GST tagged STIP1 is approximately 0.1ng/ml as a capture antibody.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, IF, IP
Primary Accession P31948
Other Accession BC002987
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 4B6
Calculated MW 62639 Da
Additional Information
Gene ID 10963
Other Names Stress-induced-phosphoprotein 1, STI1, Hsc70/Hsp90-organizing protein, Hop, Renal carcinoma antigen NY-REN-11, Transformation-sensitive protein IEF SSP 3521, STIP1
Target/Specificity STIP1 (AAH02987.1, 1 a.a. ~ 543 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsSTIP1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).

References

1.Stress-induced phosphoprotein 1 as a secreted biomarker for human ovarian cancer promotes cancer cell proliferation.Wang TH, Chao A, Tsai CL, Chang CL, Chen SH, Lee YS, Chen JK, Lin YJ, Chang PY, Wang CJ, Chao AS, Chang SD, Chang TC, Lai CH, Wang HS.Mol Cell Proteomics. 2010 May 25. [Epub ahead of print]2.Proteomic analysis of protein complexes in human SH-SY5Y neuroblastoma cells by using blue-native gel electrophoresis: An increase in lamin A/C associated with heat shock protein 90 in response to 6-hydroxydopamine-induced oxidative stress.Nakamura M, Morisawa H, Imajoh-Ohmi S, Takamura C, Fukuda H, Toda T.Exp Gerontol. 2009 Jun-Jul;44(6-7):375-82. Epub 2009 Mar 3.3.Novel Breast Cancer Metastasis-Associated Proteins.Ho J, Kong JW, Choong LY, Loh MC, Toy W, Chong PK, Wong CH, Wong CY, Shah N, Lim YP.J Proteome Res. 2009 Feb 6;8(2):583-594.

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$ 350.00
Cat# AT4076a
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Availability: 7-10 days
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