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STXBP1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant STXBP1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | P61764 |
| Other Accession | NM_003165 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 6D1 |
| Calculated MW | 67569 Da |
| Gene ID | 6812 |
|---|---|
| Other Names | Syntaxin-binding protein 1, MUNC18-1, N-Sec1, Protein unc-18 homolog 1, Unc18-1, Protein unc-18 homolog A, Unc-18A, p67, STXBP1, UNC18A |
| Target/Specificity | STXBP1 (NP_003156, 74 a.a. ~ 168 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | STXBP1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.
References
Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia. Martins-de-Souza D, et al. J Psychiatr Res, 2010 May 14. PMID 20471030.Redox proteomic analysis of carbonylated brain proteins in mild cognitive impairment and early Alzheimer's disease. Sultana R, et al. Antioxid Redox Signal, 2010 Mar. PMID 19686046.De novo STXBP1 mutations in mental retardation and nonsyndromic epilepsy. Hamdan FF, et al. Ann Neurol, 2009 Jun. PMID 19557857.Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes. Pridgeon JW, et al. FEBS J, 2009 Jan. PMID 19019082.Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux. Binda F, et al. Mol Pharmacol, 2008 Oct. PMID 18617632.
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