SUFU Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SUFU.
|Calculated MW||53947 Da|
|Other Names||Suppressor of fused homolog, SUFUH, SUFU|
|Target/Specificity||SUFU (AAH13291, 181 a.a. ~ 280 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SUFU Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.
Incomplete penetrance of the predisposition to medulloblastoma associated with germ-line SUFU mutations. Brugi?res L, et al. J Med Genet, 2010 Feb. PMID 19833601.Identification of a SUFU germline mutation in a family with Gorlin syndrome. Pastorino L, et al. Am J Med Genet A, 2009 Jul. PMID 19533801.Expression of sonic hedgehog signaling molecules in normal, hyperplastic and carcinomatous endometrium. Kim KH, et al. Pathol Int, 2009 May. PMID 19432668.Role and regulation of human tumor suppressor SUFU in Hedgehog signaling. Cheng SY, et al. Adv Cancer Res, 2008. PMID 19055941.MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation. Pizzimenti S, et al. Free Radic Biol Med, 2009 Jan 15. PMID 19022373.
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