TAC3 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant TAC3.
|Application ||WB, E|
|Calculated MW||13438 Da|
|Other Names||Tachykinin-3, ZNEUROK1, Neurokinin-B, NKB, Neuromedin-K, TAC3, NKNB|
|Target/Specificity||TAC3 (AAH32145, 17 a.a. ~ 121 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TAC3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded protein is primarily expressed in the central and peripheral nervous system and functions as a neurotransmitter. This protein is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternate splicing results in multiple transcript variants.
Common variants of the neuropeptide expressing tachykinin genes and susceptibility to asthma: a case-control study. Klassert TE, et al. J Neuroimmunol, 2010 Oct 8. PMID 20580442.Neurokinin B and its receptor in hypogonadotropic hypogonadism. Semple RK, et al. Front Horm Res, 2010. PMID 20389091.TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood. Gianetti E, et al. J Clin Endocrinol Metab, 2010 Jun. PMID 20332248.TAC3 and TACR3 defects cause hypothalamic congenital hypogonadotropic hypogonadism in humans. Young J, et al. J Clin Endocrinol Metab, 2010 May. PMID 20194706.Neurokinin B signaling in puberty: human and animal studies. Topaloglu AK. Mol Cell Endocrinol, 2010 Aug 5. PMID 20176081.
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