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TAZ Antibody (monoclonal) (M20)
Mouse monoclonal antibody raised against a full length recombinant TAZ.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q16635 |
| Other Accession | BC011515 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1E6 |
| Calculated MW | 30203 Da |
| Gene ID | 6901 |
|---|---|
| Other Names | Tafazzin, Protein G45, TAZ, EFE2, G45 |
| Target/Specificity | TAZ (AAH11515, 1 a.a. ~ 262 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TAZ Antibody (monoclonal) (M20) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that is expressed at high levels in cardiac and skeletal muscle. Mutations in this gene have been associated with a number of clinical disorders including Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Multiple transcript variants encoding different isoforms have been described. A long form and a short form of each of these isoforms is produced; the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known.
References
A novel custom resequencing array for dilated cardiomyopathy. Zimmerman RS, et al. Genet Med, 2010 May. PMID 20474083.Human transcriptional coactivator with PDZ-binding motif (TAZ) is downregulated during decidualization. Strakova Z, et al. Biol Reprod, 2010 Jun. PMID 20164440.Characterization of tafazzin splice variants from humans and fruit flies. Xu Y, et al. J Biol Chem, 2009 Oct 16. PMID 19700766.Mutations in TAZ/WWTR1, a co-activator of NKX2.1 and PAX8 are not a frequent cause of thyroid dysgenesis. Ferrara AM, et al. J Endocrinol Invest, 2009 Mar. PMID 19542741.TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. Zhang H, et al. J Biol Chem, 2009 May 15. PMID 19324877.
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