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TBL1X Antibody (monoclonal) (M07)

Mouse monoclonal antibody raised against a partial recombinant TBL1X.

  • IHC - TBL1X Antibody (monoclonal) (M07) AT4162a
    Immunoperoxidase of monoclonal antibody to TBL1X on formalin-fixed paraffin-embedded human cerebral cortex. [antibody concentration 1.5 ug/ml]
  • E - TBL1X Antibody (monoclonal) (M07) AT4162a
    Detection limit for recombinant GST tagged TBL1X is approximately 0.3ng/ml as a capture antibody.
  •  - TBL1X Antibody (monoclonal) (M07) AT4162a
    Proximity Ligation Analysis of protein-protein interactions between CACYBP and TBL1X HeLa cells were stained with anti-CACYBP rabbit purified polyclonal 1:1200 and anti-TBL1X mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O60907
Other Accession NM_005647
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2b Kappa
Clone Names 2B6
Calculated MW 62496 Da
Additional Information
Gene ID 6907
Other Names F-box-like/WD repeat-containing protein TBL1X, SMAP55, Transducin beta-like protein 1X, Transducin-beta-like protein 1, X-linked, TBL1X, TBL1
Target/Specificity TBL1X (NP_005638, 478 a.a. ~ 577 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsTBL1X Antibody (monoclonal) (M07) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene.


TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints. Perissi V, et al. Mol Cell, 2008 Mar 28. PMID 18374649.Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment. Ishii S, et al. Proc Natl Acad Sci U S A, 2008 Mar 18. PMID 18326024.TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis. Li J, et al. Nat Cell Biol, 2008 Feb. PMID 18193033.Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization. Gerlitz G, et al. Cell Cycle, 2005 Nov. PMID 16258276.Reading and function of a histone code involved in targeting corepressor complexes for repression. Yoon HG, et al. Mol Cell Biol, 2005 Jan. PMID 15601853.

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$ 315.00
Cat# AT4162a
(40 western blots)
Availability: 7-10 days
Bulk Size
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