TBL1X Antibody (monoclonal) (M07)
Mouse monoclonal antibody raised against a partial recombinant TBL1X.
|Application ||IHC, E|
|Calculated MW||62496 Da|
|Other Names||F-box-like/WD repeat-containing protein TBL1X, SMAP55, Transducin beta-like protein 1X, Transducin-beta-like protein 1, X-linked, TBL1X, TBL1|
|Target/Specificity||TBL1X (NP_005638, 478 a.a. ~ 577 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TBL1X Antibody (monoclonal) (M07) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene.
TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints. Perissi V, et al. Mol Cell, 2008 Mar 28. PMID 18374649.Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment. Ishii S, et al. Proc Natl Acad Sci U S A, 2008 Mar 18. PMID 18326024.TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis. Li J, et al. Nat Cell Biol, 2008 Feb. PMID 18193033.Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization. Gerlitz G, et al. Cell Cycle, 2005 Nov. PMID 16258276.Reading and function of a histone code involved in targeting corepressor complexes for repression. Yoon HG, et al. Mol Cell Biol, 2005 Jan. PMID 15601853.
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