TBX21 Antibody (monoclonal) (M10)
Mouse monoclonal antibody raised against a partial recombinant TBX21.
|Calculated MW||58328 Da|
|Other Names||T-box transcription factor TBX21, T-box protein 21, T-cell-specific T-box transcription factor T-bet, Transcription factor TBLYM, TBX21, TBET, TBLYM|
|Target/Specificity||TBX21 (NP_037483, 400 a.a. ~ 535 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TBX21 Antibody (monoclonal) (M10) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. Schuurhof A, et al. Pediatr Pulmonol, 2010 Jun. PMID 20503287.Association of TBX21 gene haplotypes in a Chinese population with systemic lupus erythematosus. You Y, et al. Scand J Rheumatol, 2010 May. PMID 20429676.Lck mediates Th2 differentiation through effects on T-bet and GATA-3. Kemp KL, et al. J Immunol, 2010 Apr 15. PMID 20237292.The mutations of Th1 cell-specific T-box transcription factor may be associated with a predominant Th2 phenotype in gastric cancers. Yang P, et al. Int J Immunogenet, 2010 Apr. PMID 20193034.
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