TCEB2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant TCEB2.
|Application ||WB, IF, E|
|Calculated MW||13133 Da|
|Other Names||Transcription elongation factor B polypeptide 2, Elongin 18 kDa subunit, Elongin-B, EloB, RNA polymerase II transcription factor SIII subunit B, SIII p18, TCEB2|
|Target/Specificity||TCEB2 (NP_009039, 9 a.a. ~ 118 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TCEB2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13.
Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.VHL type 2B mutations retain VBC complex form and function. Hacker KE, et al. PLoS One, 2008. PMID 19030229.Elongin B/C recruitment regulates substrate binding by CIS. Piessevaux J, et al. J Biol Chem, 2008 Aug 1. PMID 18508766.Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome. Menon S, et al. BMC Biochem, 2008 Jan 3. PMID 18173839.ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism. Ferguson JE 3rd, et al. Mol Cell Biol, 2007 Sep. PMID 17636018.
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