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TCF2 Antibody (monoclonal) (M06)

Mouse monoclonal antibody raised against a partial recombinant TCF2.

     
  • WB - TCF2 Antibody (monoclonal) (M06) AT4184a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (35.90 KDa) .
    detail
  • WB - TCF2 Antibody (monoclonal) (M06) AT4184a
    TCF2 monoclonal antibody (M06), clone 4E9. Western Blot analysis of TCF2 expression in HeLa ( (Cat # AT4184a )
    detail
  • WB - TCF2 Antibody (monoclonal) (M06) AT4184a
    TCF2 monoclonal antibody (M06), clone 4E9. Western Blot analysis of TCF2 expression in PC-12 ( (Cat # AT4184a )
    detail
  • WB - TCF2 Antibody (monoclonal) (M06) AT4184a
    TCF2 monoclonal antibody (M06), clone 4E9. Western Blot analysis of TCF2 expression in Raw 264.7((Cat # AT4184a )
    detail
  • WB - TCF2 Antibody (monoclonal) (M06) AT4184a
    TCF2 monoclonal antibody (M06), clone 4E9. Western Blot analysis of TCF2 expression in NIH/3T3((Cat # AT4184a )
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P35680
Other Accession NM_000458
Reactivity Human, Mouse, Rat
Host mouse
Clonality Monoclonal
Isotype IgG2b Kappa
Clone Names 4E10
Calculated MW 61324 Da
Additional Information
Gene ID 6928
Other Names Hepatocyte nuclear factor 1-beta, HNF-1-beta, HNF-1B, Homeoprotein LFB3, Transcription factor 2, TCF-2, Variant hepatic nuclear factor 1, vHNF1, HNF1B, TCF2
Target/Specificity TCF2 (NP_000449, 29 a.a. ~ 118 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsTCF2 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

References

Meta-analysis of genome-wide and replication association studies on prostate cancer. Liu H, et al. Prostate, 2010 Aug 5. PMID 20690139.COMMON VARIANTS IN 40 GENES ASSESSED FOR DIABETES INCIDENCE AND RESPONSE TO METFORMIN AND LIFESTYLE INTERVENTIONS IN THE DIABETES PREVENTION PROGRAM. Jablonski KA, et al. Diabetes, 2010 Aug 3. PMID 20682687.Mutations in the hepatocyte nuclear factor-1beta (HNF1B) gene are common with combined uterine and renal malformations but are not found with isolated uterine malformations. Oram RA, et al. Am J Obstet Gynecol, 2010 Jul 14. PMID 20633866.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Number of prostate cancer risk alleles may identify possibly 'insignificant' disease. Helfand BT, et al. BJU Int, 2010 Jun 30. PMID 20590552.

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$ 350.00
Cat# AT4184a
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Availability: 7-10 days
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