TCF4 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a full length recombinant TCF4.
|Application ||WB, IF, E|
|Calculated MW||71308 Da|
|Other Names||Transcription factor 4, TCF-4, Class B basic helix-loop-helix protein 19, bHLHb19, Immunoglobulin transcription factor 2, ITF-2, SL3-3 enhancer factor 2, SEF-2, TCF4, BHLHB19, ITF2, SEF2|
|Target/Specificity||TCF4 (AAH31056.1, 1 a.a. ~ 365 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TCF4 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes transcription factor 4, a basic helix-turn-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is expressed predominantly in pre-B-cells, although it is found in other tissues as well. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq]
1.Knockdown of Human TCF4 Affects Multiple Signaling Pathways Involved in Cell Survival, Epithelial to Mesenchymal Transition and Neuronal Differentiation.Forrest MP, Waite AJ, Martin-Rendon E, Blake DJ.PLoS One. 2013 Aug 23;8(8):e73169.2.Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis.Tanaka A, Itoh F, Nishiyama K, Takezawa T, Kurihara H, Itoh S, Kato M.Blood. 2010 May 20;115(20):4138-47. Epub 2010 Mar 15.
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