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TCF7L2 Antibody (monoclonal) (M03)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT4190a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
TCF7L2 Antibody (monoclonal) (M03) - Product info | |
| Application | IF, WB
|
| Primary Accession | Q9NQB0 |
| Other Accession | NP_110383 |
| Reactivity | Human |
| Isotype | IgG1 Kappa |
| Clone Names | 3D7 |
| Calculated MW | 67919 Da |
TCF7L2 Antibody (monoclonal) (M03) - Additional info | |
| Gene ID 6934 | |
| Other Names TCF4, TCF4transcription factor 7-like 2 (T-cell specific, HMG-box) | |
| Target/Specificity TCF7L2 (NP_110383, 490 a.a. ~ 597 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Dilution WB~~1:500~1000 | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions TCF7L2 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. | |
TCF7L2 Antibody (monoclonal) (M03) - Related products
AP12416a: TCF7L2 Antibody (N-term)
RI15258: TCF7L2 predesign siRNA
AT4190a: TCF7L2 Antibody (monoclonal) (M03)
TCF7L2 Antibody (monoclonal) (M03) - Application data
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Immunofluorescence of monoclonal antibody to TCF7L2 (AT4190a) on HeLa cell . [antibody concentration 40 ug/ml]
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TCF7L2 monoclonal antibody (M03), clone 3D7 Western Blot analysis of TCF7L2 expression in K-562 ( Cat # L009V1 ).
TCF7L2 Antibody (monoclonal) (M03) - Research Areas
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BACKGROUND
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes.
REFERENCES
Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion. Heni M, et al. Diabetes, 2010 Aug 29. PMID 20802253.Role of BMI in the Association of the TCF7L2 rs7903146 Variant with Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study. Kucharska-Newton AM, et al. J Obes, 2010. PMID 20798759.Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: common genetic variants in GCK and TCF7L2 are associated with fasting and post-challenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes from the International Association of Diabetes and Pregnancy Study Groups. Freathy RM, et al. Diabetes, 2010 Aug 3. PMID 20682688.The balance of TCF7L2 variants with differential activities in Wnt-signaling is regulated by lithium in a GSK3beta-independent manner. Struewing I, et al. Biochem Biophys Res Commun, 2010 Aug 20. PMID 20654575.Potential role of TCF7L2 gene variants on cardiac sympathetic/parasympathetic activity. Boccardi V, et al. Eur J Hum Genet, 2010 Jul 21. PMID 20648057.
