TCF7L2 Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a partial recombinant TCF7L2.
|Application ||WB, IHC, IF, E|
|Calculated MW||67919 Da|
|Other Names||Transcription factor 7-like 2, HMG box transcription factor 4, T-cell-specific transcription factor 4, T-cell factor 4, TCF-4, hTCF-4, TCF7L2, TCF4|
|Target/Specificity||TCF7L2 (NP_110383, 490 a.a. ~ 596 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TCF7L2 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes.
Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion. Heni M, et al. Diabetes, 2010 Aug 29. PMID 20802253.Role of BMI in the Association of the TCF7L2 rs7903146 Variant with Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study. Kucharska-Newton AM, et al. J Obes, 2010. PMID 20798759.Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: common genetic variants in GCK and TCF7L2 are associated with fasting and post-challenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes from the International Association of Diabetes and Pregnancy Study Groups. Freathy RM, et al. Diabetes, 2010 Aug 3. PMID 20682688.The balance of TCF7L2 variants with differential activities in Wnt-signaling is regulated by lithium in a GSK3beta-independent manner. Struewing I, et al. Biochem Biophys Res Commun, 2010 Aug 20. PMID 20654575.Potential role of TCF7L2 gene variants on cardiac sympathetic/parasympathetic activity. Boccardi V, et al. Eur J Hum Genet, 2010 Jul 21. PMID 20648057.
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