TEAD4 Antibody (monoclonal) (M12)
Mouse monoclonal antibody raised against a full length recombinant TEAD4.
|Application ||WB, IHC|
|Calculated MW||48329 Da|
|Other Names||Transcriptional enhancer factor TEF-3, TEA domain family member 4, TEAD-4, Transcription factor 13-like 1, Transcription factor RTEF-1, TEAD4, RTEF1, TCF13L1, TEF3|
|Target/Specificity||TEAD4 (AAH15497, 1 a.a. ~ 361 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TEAD4 Antibody (monoclonal) (M12) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene.
TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. Zhang H, et al. J Biol Chem, 2009 May 15. PMID 19324877.Transcription enhancer factor 3 (TEF3) mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cells. Liu X, et al. J Biol Chem, 2008 Dec 5. PMID 18840614.TEAD mediates YAP-dependent gene induction and growth control. Zhao B, et al. Genes Dev, 2008 Jul 15. PMID 18579750.Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies. Sakai N, et al. J Endocrinol, 2008 Sep. PMID 18579725.Identification of novel alternatively spliced isoforms of RTEF-1 within human ocular vascular endothelial cells and murine retina. Appukuttan B, et al. Invest Ophthalmol Vis Sci, 2007 Aug. PMID 17652751.
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