TEBP Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant TEBP.
|Application ||WB, IHC, E|
|Calculated MW||18697 Da|
|Other Names||Prostaglandin E synthase 3, Cytosolic prostaglandin E2 synthase, cPGES, Hsp90 co-chaperone, Progesterone receptor complex p23, Telomerase-binding protein p23, PTGES3, P23, TEBP|
|Target/Specificity||TEBP (AAH03005, 1 a.a. ~ 160 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TEBP Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function. Mollapour M, et al. Mol Cell, 2010 Feb 12. PMID 20159553.Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23. Chadli A, et al. J Biol Chem, 2010 Feb 5. PMID 19996313.Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. Lee JH, et al. Cancer Lett, 2010 Apr 1. PMID 19751963.A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function. Woo SH, et al. J Biol Chem, 2009 Nov 6. PMID 19740745.The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas. Mattila S, et al. Neuropathology, 2009 Apr. PMID 19347995.
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