TFAP2B Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant TFAP2B.
|Application ||WB, IF|
|Calculated MW||50474 Da|
|Other Names||Transcription factor AP-2-beta, AP2-beta, Activating enhancer-binding protein 2-beta, TFAP2B|
|Target/Specificity||TFAP2B (NP_003212, 73 a.a. ~ 182 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TFAP2B Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.
Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population. Hotta K, et al. J Hum Genet, 2010 Aug 12. PMID 20703240.Transcription factor AP2 beta involved in severe female alcoholism. Nordquist N, et al. Brain Res, 2009 Dec 11. PMID 19778525.Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. Lindgren CM, et al. PLoS Genet, 2009 Jun. PMID 19557161.Determination of genetic predisposition to patent ductus arteriosus in preterm infants. Dagle JM, et al. Pediatrics, 2009 Apr. PMID 19336370.The transcription factor TFAP2B is associated with insulin resistance and adiposity in healthy adolescents. Nordquist N, et al. Obesity (Silver Spring), 2009 Sep. PMID 19325541.
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