TFB1M Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full-length recombinant TFB1M.
|Calculated MW||39543 Da|
|Other Names||Dimethyladenosine transferase 1, mitochondrial, 211-, Mitochondrial 12S rRNA dimethylase 1, Mitochondrial transcription factor B1, h-mtTFB, h-mtTFB1, hTFB1M, mtTFB1, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1, TFB1M|
|Target/Specificity||TFB1M (AAH17788, 1 a.a. ~ 346 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TFB1M Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).
Training response of mitochondrial transcription factors in human skeletal muscle. Norrbom J, et al. Acta Physiol (Oxf), 2010 Jan. PMID 19681768.Elucidation of separate, but collaborative functions of the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafness. Cotney J, et al. Hum Mol Genet, 2009 Jul 15. PMID 19417006.Mitochondrial transcription factors TFA, TFB1 and TFB2: a search for DNA variants/haplotypes and the risk of cardiac hypertrophy. Alonso-Montes C, et al. Dis Markers, 2008. PMID 19096125.Mutational screening of the mitochondrial transcription factors B1 and B2 (TFB1M and TFB2M) in Parkinson's disease. S?nchez-Ferrero E, et al. Parkinsonism Relat Disord, 2009 Jul. PMID 18980857.The layered structure of human mitochondrial DNA nucleoids. Bogenhagen DF, et al. J Biol Chem, 2008 Feb 8. PMID 18063578.
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