TGFB1I1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant TGFB1I1.
|Application ||WB, E|
|Calculated MW||49814 Da|
|Other Names||Transforming growth factor beta-1-induced transcript 1 protein, Androgen receptor coactivator 55 kDa protein, Androgen receptor-associated protein of 55 kDa, Hydrogen peroxide-inducible clone 5 protein, Hic-5, TGFB1I1, ARA55|
|Target/Specificity||TGFB1I1 (AAH32545, 1 a.a. ~ 444 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TGFB1I1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Paxillin and hydrogen peroxide-inducible clone 5 expression and distribution in control and Alzheimer disease hippocampi. Caltagarone J, et al. J Neuropathol Exp Neurol, 2010 Apr. PMID 20448481.In vitro and in vivo evidence of pathogenic roles of Hic-5/ARA55 in keloids through Smad pathway and profibrotic transcription. Inui S, et al. J Dermatol Sci, 2010 May. PMID 20395114.Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. Jones CA, et al. Nat Cell Biol, 2009 Nov. PMID 19855388.The progesterone receptor coactivator Hic-5 is involved in the pathophysiology of endometriosis. Aghajanova L, et al. Endocrinology, 2009 Aug. PMID 19389829.Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55. Wang H, et al. Oncogene, 2008 Nov 20. PMID 18762808.
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