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THAP1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant THAP1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF |
|---|---|
| Primary Accession | Q9NVV9 |
| Other Accession | BC021721 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 2C1-2F2 |
| Calculated MW | 24944 Da |
| Gene ID | 55145 |
|---|---|
| Other Names | THAP domain-containing protein 1, THAP1 |
| Target/Specificity | THAP1 (AAH21721, 1 a.a. ~ 213 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | THAP1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
References
Prevalence of THAP1 sequence variants in German patients with primary dystonia. S?hn AS, et al. Mov Disord, 2010 Sep 15. PMID 20669277.THAP1 mutations (DYT6) are an additional cause of early-onset dystonia. Houlden H, et al. Neurology, 2010 Mar 9. PMID 20211909.The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias. Mazars R, et al. J Biol Chem, 2010 Apr 30. PMID 20200153.Structural determinants of specific DNA-recognition by the THAP zinc finger. Campagne S, et al. Nucleic Acids Res, 2010 Jun. PMID 20144952.Novel THAP1 sequence variants in primary dystonia. Xiao J, et al. Neurology, 2010 Jan 19. PMID 20083799.
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