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TIMP2 Antibody (monoclonal) (M02J)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT4244a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
TIMP2 Antibody (monoclonal) (M02J) - Product info | |
| Application | IF
|
| Primary Accession | P16035 |
| Reactivity | Human |
| Isotype | IgG2a Kappa |
| Clone Names | 4F5 |
| Calculated MW | 24399 Da |
TIMP2 Antibody (monoclonal) (M02J) - Additional info | |
| Gene ID 7077 | |
| Other Names CSC21KTIMP metallopeptidase inhibitor 2 | |
| Target/Specificity TIMP2 (AAH52605, 27 a.a. ~ 221 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions TIMP2 Antibody (monoclonal) (M02J) is for research use only and not for use in diagnostic or therapeutic procedures. | |
TIMP2 Antibody (monoclonal) (M02J) - Application data
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Immunofluorescence of monoclonal antibody to TIMP2 (AT4244a) on HeLa cell . [antibody concentration 10 ug/ml]
TIMP2 Antibody (monoclonal) (M02J) - Related products
RI15323: TIMP2 predesign siRNA
AT4243a: TIMP2 Antibody (monoclonal) (M01J)
AT4244a: TIMP2 Antibody (monoclonal) (M02J)
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BACKGROUND
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
REFERENCES
Clinical Impact of MMP and TIMP Gene Polymorphisms in Gastric Cancer. Alakus H, et al. World J Surg, 2010 Aug 21. PMID 20730428.Matrix metalloproteinase-3 promoter polymorphisms but not dupA-H. pylori correlate to duodenal ulcers in H. pylori-infected females. Yeh YC, et al. BMC Microbiol, 2010 Aug 13. PMID 20707923.Common genetic polymorphisms in Moyamoya and atherosclerotic disease in Europeans. Roder C, et al. Childs Nerv Syst, 2010 Aug 6. PMID 20694560.A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). Romero R, et al. Am J Obstet Gynecol, 2010 Jul 29. PMID 20673868.Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. Nikopensius T, et al. Birth Defects Res A Clin Mol Teratol, 2010 Jul 29. PMID 20672350.
