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TLX3 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant TLX3.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O43711 |
| Other Accession | NM_021025 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 5B11 |
| Calculated MW | 31867 Da |
| Gene ID | 30012 |
|---|---|
| Other Names | T-cell leukemia homeobox protein 3, Homeobox protein Hox-11L2, TLX3, HOX11L2 |
| Target/Specificity | TLX3 (NP_066305, 192 a.a. ~ 291 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TLX3 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993 [PubMed 8099440]).
References
Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group. Baak U, et al. Leukemia, 2008 Jun. PMID 18368072.Cooperative genetic defects in TLX3 rearranged pediatric T-ALL. Van Vlierberghe P, et al. Leukemia, 2008 Apr. PMID 18185524.Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1. Nagel S, et al. Cancer Res, 2007 Feb 15. PMID 17308084.Nuclear factor Y drives basal transcription of the human TLX3, a gene overexpressed in T-cell acute lymphocytic leukemia. Borghini S, et al. Mol Cancer Res, 2006 Sep. PMID 16966433.Significance of HOX11L2/TLX3 expression in children with T-cell acute lymphoblastic leukemia treated on Children's Cancer Group protocols. Gottardo NG, et al. Leukemia, 2005 Sep. PMID 15990867.
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