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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   TLX3 Antibody (monoclonal) (M02)   

TLX3 Antibody (monoclonal) (M02)

Mouse monoclonal antibody raised against a partial recombinant TLX3.

  • WB - TLX3 Antibody (monoclonal) (M02) AT4261a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
  • E - TLX3 Antibody (monoclonal) (M02) AT4261a
    Detection limit for recombinant GST tagged TLX3 is approximately 0.03ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43711
Other Accession NM_021025
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 5B11
Calculated MW 31867 Da
Additional Information
Gene ID 30012
Other Names T-cell leukemia homeobox protein 3, Homeobox protein Hox-11L2, TLX3, HOX11L2
Target/Specificity TLX3 (NP_066305, 192 a.a. ~ 291 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsTLX3 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993 [PubMed 8099440]).


Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group. Baak U, et al. Leukemia, 2008 Jun. PMID 18368072.Cooperative genetic defects in TLX3 rearranged pediatric T-ALL. Van Vlierberghe P, et al. Leukemia, 2008 Apr. PMID 18185524.Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1. Nagel S, et al. Cancer Res, 2007 Feb 15. PMID 17308084.Nuclear factor Y drives basal transcription of the human TLX3, a gene overexpressed in T-cell acute lymphocytic leukemia. Borghini S, et al. Mol Cancer Res, 2006 Sep. PMID 16966433.Significance of HOX11L2/TLX3 expression in children with T-cell acute lymphoblastic leukemia treated on Children's Cancer Group protocols. Gottardo NG, et al. Leukemia, 2005 Sep. PMID 15990867.

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$ 315.00
Cat# AT4261a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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