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TNFSF12 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant TNFSF12.

  • WB - TNFSF12 Antibody (monoclonal) (M01) AT4285a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (35.2 KDa) .
  • WB - TNFSF12 Antibody (monoclonal) (M01) AT4285a
    TNFSF12 monoclonal antibody (M01), clone 4H3. Western Blot analysis of TNFSF12 expression in Raw 264.7.
  • E - TNFSF12 Antibody (monoclonal) (M01) AT4285a
    Detection limit for recombinant GST tagged TNFSF12 is approximately 0.03ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43508
Other Accession BC019047
Reactivity Human, Mouse
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 4H3
Calculated MW 27216 Da
Additional Information
Gene ID 407977;8742
Other Names Tumor necrosis factor ligand superfamily member 12, APO3 ligand, TNF-related weak inducer of apoptosis, TWEAK, Tumor necrosis factor ligand superfamily member 12, membrane form, Tumor necrosis factor ligand superfamily member 12, secreted form, TNFSF12, APO3L, DR3LG
Target/Specificity TNFSF12 (AAH19047, 49 a.a. ~ 134 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsTNFSF12 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Some transcripts that skip the last exon of this gene and continue with the second exon of the neighboring TNFSF13 gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.


Anti-C1q antibodies, sCD40L, TWEAK and CD4/CD8 ratio in systemic lupus erythematosus and their relations to disease activity and renal involvement. ElGendi SS, et al. Egypt J Immunol, 2009. PMID 20726330.Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway. Roos C, et al. J Immunol, 2010 Aug 1. PMID 20610643.Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway. Brown SA, et al. J Biol Chem, 2010 Jun 4. PMID 20385556.Tumor necrosis-like weak inducer of apoptosis as a proinflammatory cytokine in human adipocyte cells: up-regulation in severe obesity is mediated by inflammation but not hypoxia. Vendrell J, et al. J Clin Endocrinol Metab, 2010 Jun. PMID 20382683.Peripheral artery disease is associated with a high CD163/TWEAK plasma ratio. Moreno JA, et al. Arterioscler Thromb Vasc Biol, 2010 Jun. PMID 20299688.

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$ 315.00
Cat# AT4285a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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