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TNFSF12 Antibody (monoclonal) (M01)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT4285a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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TNFSF12 Antibody (monoclonal) (M01) - Product info | |
| Primary Accession | O43508 |
| Reactivity | Human |
| Isotype | IgG2a Kappa |
| Clone Names | 4H3 |
| Calculated MW | 27216 Da |
TNFSF12 Antibody (monoclonal) (M01) - Additional info | |
| Gene ID 8742 | |
| Other Names APO3L, DR3LG, MGC20669, TWEAKtumor necrosis factor (ligand) superfamily, member 12 | |
| Target/Specificity TNFSF12 (AAH19047, 49 a.a. ~ 135 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions TNFSF12 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. | |
TNFSF12 Antibody (monoclonal) (M01) - Application data
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Detection limit for recombinant GST tagged TNFSF12 is approximately 0.03ng/ml as a capture antibody.
TNFSF12 Antibody (monoclonal) (M01) - Related products
RI15383: TNFSF12 predesign siRNA
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BACKGROUND
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Some transcripts that skip the last exon of this gene and continue with the second exon of the neighboring TNFSF13 gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
REFERENCES
Anti-C1q antibodies, sCD40L, TWEAK and CD4/CD8 ratio in systemic lupus erythematosus and their relations to disease activity and renal involvement. ElGendi SS, et al. Egypt J Immunol, 2009. PMID 20726330.Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway. Roos C, et al. J Immunol, 2010 Aug 1. PMID 20610643.Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway. Brown SA, et al. J Biol Chem, 2010 Jun 4. PMID 20385556.Tumor necrosis-like weak inducer of apoptosis as a proinflammatory cytokine in human adipocyte cells: up-regulation in severe obesity is mediated by inflammation but not hypoxia. Vendrell J, et al. J Clin Endocrinol Metab, 2010 Jun. PMID 20382683.Peripheral artery disease is associated with a high CD163/TWEAK plasma ratio. Moreno JA, et al. Arterioscler Thromb Vasc Biol, 2010 Jun. PMID 20299688.
