TNP1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant TNP1.
|Application ||WB, IHC, E|
|Calculated MW||6424 Da|
|Other Names||Spermatid nuclear transition protein 1, STP-1, TP-1, TNP1|
|Target/Specificity||TNP1 (AAH29516.1, 1 a.a. ~ 55 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TNP1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).
The TNP1 haplotype - GCG is associated with azoospermia. Khattri A, et al. Int J Androl, 2010 May 26. PMID 20522125.Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. Aston KI, et al. Hum Reprod, 2010 Jun. PMID 20378615.Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. Pillas D, et al. PLoS Genet, 2010 Feb 26. PMID 20195514.A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Thomas G, et al. Nat Genet, 2009 May. PMID 19330030.Spermiogenesis defects in human: detection of transition proteins in semen from some infertile men. Becker S, et al. Andrologia, 2008 Aug. PMID 18727729.
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