TOPORS Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant TOPORS.
|Application ||WB, IHC, IF, E|
|Calculated MW||119198 Da|
|Other Names||E3 ubiquitin-protein ligase Topors, 632-, SUMO1-protein E3 ligase Topors, Topoisomerase I-binding RING finger protein, Topoisomerase I-binding arginine/serine-rich protein, Tumor suppressor p53-binding protein 3, p53-binding protein 3, p53BP3, TOPORS, LUN, TP53BPL|
|Target/Specificity||TOPORS (NP_005793, 98 a.a. ~ 205 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TOPORS Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus.
1.Mitotic Phosphorylation Stimulates DNA Relaxation Activity of Human Topoisomerase I.Hackbarth JS, Galvez-Peralta M, Dai NT, Loegering DA, Peterson KL, Meng XW, Karnitz LM, Kaufmann SH.J Biol Chem. 2008 Jun 13;283(24):16711-22. Epub 2008 Apr 11.
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