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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Amyotrophic Lateral Sclerosis (ALS)   >   TP53 Antibody (monoclonal) (M01)   

TP53 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant TP53.

  • WB - TP53 Antibody (monoclonal) (M01) AT4310a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.62 KDa) .
  • WB - TP53 Antibody (monoclonal) (M01) AT4310a
    TP53 monoclonal antibody (M01), clone 2C3 Western Blot analysis of TP53 expression in A-431 ( (Cat # AT4310a )
  • WB - TP53 Antibody (monoclonal) (M01) AT4310a
    Western Blot analysis of TP53 expression in transfected 293T cell line by TP53 monoclonal antibody (M01), clone 2C3.

    Lane 1: TP53 transfected lysate(43.7 KDa).
    Lane 2: Non-transfected lysate.
  • IHC - TP53 Antibody (monoclonal) (M01) AT4310a
    Immunoperoxidase of monoclonal antibody to TP53 on formalin-fixed paraffin-embedded human salivary gland. [antibody concentration 3 ug/ml]
  • IF - TP53 Antibody (monoclonal) (M01) AT4310a
    Immunofluorescence of monoclonal antibody to TP53 on A-431 cell. [antibody concentration 10 ug/ml]
  • IP - TP53 Antibody (monoclonal) (M01) AT4310a
    Immunoprecipitation of TP53 transfected lysate using anti-TP53 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with TP53 MaxPab rabbit polyclonal antibody.
  • E - TP53 Antibody (monoclonal) (M01) AT4310a
    Detection limit for recombinant GST tagged TP53 is approximately 1ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P04637
Other Accession BC003596
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 2C3
Calculated MW 43653 Da
Additional Information
Gene ID 7157
Other Names Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53, P53
Target/Specificity TP53 (AAH03596, 94 a.a. ~ 201 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsTP53 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity.


Hepatocellular carcinoma and the underlying mechanisms. Oyagbemi AA, et al. Afr Health Sci, 2010 Mar. PMID 20811532.PTEN tumor suppressor plays less prognostic role than P53 tumor suppressor in diffuse large B-cell lymphoma. Liu YY, et al. Leuk Lymphoma, 2010 Sep. PMID 20807096.BRAF Mutation Is Rare in Advanced-Stage Low-Grade Ovarian Serous Carcinomas. Wong KK, et al. Am J Pathol, 2010 Aug 27. PMID 20802181.Role of p53 and p21 polymorphisms in the risk of cervical cancer among Chinese women. Jiang P, et al. Acta Biochim Biophys Sin (Shanghai), 2010 Sep. PMID 20732856.Association of Glutathione S-Transferase, EPHX, and p53 codon 72 Gene Polymorphisms with Adult Acute Myeloid Leukemia. Chauhan PS, et al. DNA Cell Biol, 2010 Aug 23. PMID 20731606.

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$ 315.00
Cat# AT4310a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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