TPMT Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a full length recombinant TPMT.
|Application ||WB, IF, E|
|Calculated MW||28180 Da|
|Other Names||Thiopurine S-methyltransferase, Thiopurine methyltransferase, TPMT|
|Target/Specificity||TPMT (AAH05339, 1 a.a. ~ 245 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TPMT Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Thiopurine S-methyltransferase polymorphisms and thiopurine toxicity in treatment of inflammatory bowel disease. Dong XW, et al. World J Gastroenterol, 2010 Jul 7. PMID 20593505.Genetic analysis of thiopurine methyltransferase polymorphism in the Jordanian population. Hakooz N, et al. Eur J Clin Pharmacol, 2010 Oct. PMID 20521035.Frequency of thiopurine S-methyltransferase (TPMT) alleles in southeast Iranian population. Bahari A, et al. Nucleosides Nucleotides Nucleic Acids, 2010 Mar. PMID 20408054.Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer. Lipkin SM, et al. Cancer Prev Res (Phila), 2010 May. PMID 20403997.
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