TRIB2 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant TRIB2.
|Application ||WB, IHC, E|
|Calculated MW||38801 Da|
|Other Names||Tribbles homolog 2, TRB-2, TRIB2 (HGNC:30809)|
|Target/Specificity||TRIB2 (NP_067675, 254 a.a. ~ 343 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TRIB2 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
1.Ubiquitin E3 ligase SCF?-TRCP regulates TRIB2 stability in liver cancer cells.Qiao Y, Zhang Y, Wang JBiochem Biophys Res Commun. 2013 Nov 5. pii: S0006-291X(13)01814-7. doi: 10.1016/j.bbrc.2013.10.123.2.Impaired phosphorylation and ubiquitination by P70 S6 kinase (P70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promotes Tribbles homolog 2 (TRIB2) stability and carcinogenic property in liver cancer.Wang J, Zhang Y, Weng W, Qiao Y, Ma L, Xiao W, Yu Y, Pan Q, Sun FJ Biol Chem. 2013 Oct 2.
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