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TRIB2 Antibody (monoclonal) (M04)

Mouse monoclonal antibody raised against a partial recombinant TRIB2.

  • WB - TRIB2 Antibody (monoclonal) (M04) AT4338a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (35.64 KDa) .
  • WB - TRIB2 Antibody (monoclonal) (M04) AT4338a
    Western Blot analysis of TRIB2 expression in transfected 293T cell line by TRIB2 monoclonal antibody (M04), clone 1B1.

    Lane 1: TRIB2 transfected lysate(38.8 KDa).
    Lane 2: Non-transfected lysate.
  • IHC - TRIB2 Antibody (monoclonal) (M04) AT4338a
    Immunoperoxidase of monoclonal antibody to TRIB2 on formalin-fixed paraffin-embedded human colon. [antibody concentration 3 ug/ml]
  • E - TRIB2 Antibody (monoclonal) (M04) AT4338a
    Detection limit for recombinant GST tagged TRIB2 is approximately 0.03ng/ml as a capture antibody.
  • WB - TRIB2 Antibody (monoclonal) (M04) AT4338a
    Western blot analysis of TRIB2 over-expressed 293 cell line, cotransfected with TRIB2 Validated Chimera RNAi ( (Cat # AT4338a )
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92519
Other Accession NM_021643
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2b Lambda
Clone Names 1B1
Calculated MW 38801 Da
Additional Information
Gene ID 28951
Other Names Tribbles homolog 2, TRB-2, TRIB2 (HGNC:30809)
Target/Specificity TRIB2 (NP_067675, 254 a.a. ~ 343 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsTRIB2 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.


1.Ubiquitin E3 ligase SCF?-TRCP regulates TRIB2 stability in liver cancer cells.Qiao Y, Zhang Y, Wang JBiochem Biophys Res Commun. 2013 Nov 5. pii: S0006-291X(13)01814-7. doi: 10.1016/j.bbrc.2013.10.123.2.Impaired phosphorylation and ubiquitination by P70 S6 kinase (P70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promotes Tribbles homolog 2 (TRIB2) stability and carcinogenic property in liver cancer.Wang J, Zhang Y, Weng W, Qiao Y, Ma L, Xiao W, Yu Y, Pan Q, Sun FJ Biol Chem. 2013 Oct 2.

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$ 315.00
Cat# AT4338a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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