TRIM33 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant TRIM33.
|Application ||WB, IHC, IF, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||122533 Da|
|Other Names||E3 ubiquitin-protein ligase TRIM33, 632-, Ectodermin homolog, RET-fused gene 7 protein, Protein Rfg7, Transcription intermediary factor 1-gamma, TIF1-gamma, Tripartite motif-containing protein 33, TRIM33, KIAA1113, RFG7, TIF1G|
|Target/Specificity||TRIM33 (NP_056990, 1006 a.a. ~ 1105 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TRIM33 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.
TIF1gamma controls erythroid cell fate by regulating transcription elongation. Bai X, et al. Cell, 2010 Jul 9. PMID 20603019.Transcription intermediary factor 1gamma decreases protein expression of the transcriptional cofactor, LIM-domain-binding 1. Howard PW, et al. Biochem Biophys Res Commun, 2010 Jun 4. PMID 20447379.Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas. Vincent DF, et al. PLoS Genet, 2009 Jul. PMID 19629168.FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Dupont S, et al. Cell, 2009 Jan 9. PMID 19135894.Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
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