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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   TRIM63 Antibody (monoclonal) (M01)   

TRIM63 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant TRIM63.

  • WB - TRIM63 Antibody (monoclonal) (M01) AT4361a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) .
  • WB - TRIM63 Antibody (monoclonal) (M01) AT4361a
    Western Blot analysis of TRIM63 expression in transfected 293T cell line by TRIM63 monoclonal antibody (M01), clone 6G6.

    Lane 1: TRIM63 transfected lysate(40.2 KDa).
    Lane 2: Non-transfected lysate.
  • IF - TRIM63 Antibody (monoclonal) (M01) AT4361a
    Immunofluorescence of monoclonal antibody to TRIM63 on HeLa cell . [antibody concentration 10 ug/ml]
  • E - TRIM63 Antibody (monoclonal) (M01) AT4361a
    Detection limit for recombinant GST tagged TRIM63 is approximately 0.1ng/ml as a capture antibody.
  • WB - TRIM63 Antibody (monoclonal) (M01) AT4361a
    Western blot analysis of TRIM63 over-expressed 293 cell line, cotransfected with TRIM63 Validated Chimera RNAi ( (Cat # AT4361a )
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q969Q1
Other Accession NM_032588
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 6G6
Calculated MW 40248 Da
Additional Information
Gene ID 84676
Other Names E3 ubiquitin-protein ligase TRIM63, 632-, Iris RING finger protein, Muscle-specific RING finger protein 1, MuRF-1, MuRF1, RING finger protein 28, Striated muscle RING zinc finger protein, Tripartite motif-containing protein 63, TRIM63, IRF, MURF1, RNF28, SMRZ
Target/Specificity TRIM63 (NP_115977, 254 a.a. ~ 352 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsTRIM63 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.


Depressed expression of MuRF1 and MAFbx in areas remote of recent myocardial infarction: a mechanism contributing to myocardial remodeling? Conraads VM, et al. Basic Res Cardiol, 2010 Mar. PMID 19859778.Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms. Mearini G, et al. Cardiovasc Res, 2010 Jan 15. PMID 19850579.Atrogin-1, MuRF1, and FoXO, as well as phosphorylated GSK-3beta and 4E-BP1 are reduced in skeletal muscle of chronic spinal cord-injured patients. L?ger B, et al. Muscle Nerve, 2009 Jul. PMID 19533653.Structural analysis of B-Box 2 from MuRF1: identification of a novel self-association pattern in a RING-like fold. Mrosek M, et al. Biochemistry, 2008 Oct 7. PMID 18795805.The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene. Waddell DS, et al. Am J Physiol Endocrinol Metab, 2008 Oct. PMID 18612045.

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$ 315.00
Cat# AT4361a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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