TRIP6 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant TRIP6.
|Application ||WB, IF, E|
|Calculated MW||50288 Da|
|Other Names||Thyroid receptor-interacting protein 6, TR-interacting protein 6, TRIP-6, Opa-interacting protein 1, OIP-1, Zyxin-related protein 1, ZRP-1, TRIP6, OIP1|
|Target/Specificity||TRIP6 (NP_003293, 51 a.a. ~ 148 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TRIP6 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect. E S, et al. J Biol Chem, 2009 May 22. PMID 19293149.IL-12 stimulates the osteoclast inhibitory peptide-1 (OIP-1/hSca) gene expression in CD4+ T cells. Shanmugarajan S, et al. J Cell Biochem, 2009 May 1. PMID 19259951.An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904.TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness. Chastre E, et al. FASEB J, 2009 Mar. PMID 19017743.Osteoclast inhibitory peptide-1 (OIP-1) inhibits measles virus nucleocapsid protein stimulated osteoclast formation/activity. Shanmugarajan S, et al. J Cell Biochem, 2008 Jul 1. PMID 18348201.
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