TRPV1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant TRPV1.
|Application ||WB, E|
|Calculated MW||94956 Da|
|Other Names||Transient receptor potential cation channel subfamily V member 1, TrpV1, Capsaicin receptor, Osm-9-like TRP channel 1, OTRPC1, Vanilloid receptor 1, TRPV1, VR1|
|Target/Specificity||TRPV1 (NP_542437, 21 a.a. ~ 124 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TRPV1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.
1.Human odontoblasts express functional thermo-sensitive TRP channels: Implications for dentin sensitivity.El Karim IA, Linden GJ, Curtis TM, About I, McGahon MK, Irwin CR, Lundy FT.Pain. 2010 Dec 16. [Epub ahead of print]2.Endogenous expression of TRPV1 channel in cultured human melanocytes.Endogenous expression of TRPV1 channel in cultured human melanocytes.J Dermatol Sci. 2009 Nov;56(2):128-30. Epub 2009 Aug 4.
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