TSC22D3 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant TSC22D3.
|Application ||WB, IHC, IF, IP, E|
|Calculated MW||14810 Da|
|Other Names||TSC22 domain family protein 3, DSIP-immunoreactive peptide, Protein DIP, hDIP, Delta sleep-inducing peptide immunoreactor, Glucocorticoid-induced leucine zipper protein, GILZ, TSC-22-like protein, TSC-22-related protein, TSC-22R, TSC22D3, DSIPI, GILZ|
|Target/Specificity||TSC22D3 (NP_932174, 1 a.a. ~ 97 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TSC22D3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene.
Glucocorticoid-induced leucine zipper (GILZ) promotes the nuclear exclusion of FOXO3 in a Crm1-dependent manner. Latr? de Lat? P, et al. J Biol Chem, 2010 Feb 19. PMID 20018851.The glucocorticoid-induced leucine zipper gene (GILZ) expression decreases after successful treatment of patients with endogenous Cushing's syndrome and may play a role in glucocorticoid-induced osteoporosis. Lekva T, et al. J Clin Endocrinol Metab, 2010 Jan. PMID 19875485.Identification of glucocorticoid-induced leucine zipper as a key regulator of tumor cell proliferation in epithelial ovarian cancer. Redjimi N, et al. Mol Cancer, 2009 Oct 8. PMID 19814803.Epithelial sodium channel regulated by differential composition of a signaling complex. Soundararajan R, et al. Proc Natl Acad Sci U S A, 2009 May 12. PMID 19380724.Chronic rhinosinusitis with and without nasal polyps is associated with decreased expression of glucocorticoid-induced leucine zipper. Zhang XH, et al. Clin Exp Allergy, 2009 May. PMID 19260870.
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