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TUBA2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant TUBA2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | Q13748 |
| Other Accession | BC011721 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 3F10-2F2 |
| Other Names | Tubulin alpha-3C/D chain, Alpha-tubulin 2, Alpha-tubulin 3C/D, Tubulin alpha-2 chain, TUBA3C, TUBA2 |
|---|---|
| Target/Specificity | TUBA2 (AAH11721.1, 1 a.a. ~ 418 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TUBA2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene is an alpha tubulin gene that encodes a protein 99% identical to the mouse testis-specific Tuba3 and Tuba7 gene products. This gene is located in the 13q11 region, which is associated with the genetic diseases Clouston hidrotic ectodermal dysplasia and Kabuki syndrome.
References
Inhibitory effect of HIV-1 Tat protein on the sodium-D-glucose symporter of human intestinal epithelial cells. Canani RB, et al. AIDS, 2006 Jan 2. PMID 16327313.Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514.Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection. Valenzuela-Fern?ndez A, et al. Mol Biol Cell, 2005 Nov. PMID 16148047.HIV-1 Tat, apoptosis and the mitochondria: a tubulin link? Giacca M. Retrovirology, 2005 Feb 7. PMID 15698476.HIV-1 Tat protein enhances microtubule polymerization. de Mareuil J, et al. Retrovirology, 2005 Feb 3. PMID 15691386.
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