TWIST1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant TWIST1.
|Application ||WB, IP|
|Calculated MW||20954 Da|
|Other Names||Twist-related protein 1, Class A basic helix-loop-helix protein 38, bHLHa38, H-twist, TWIST1, BHLHA38, TWIST|
|Target/Specificity||TWIST1 (NP_000465, 100 a.a. ~ 202 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TWIST1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome.
1.Cellular migration and invasion uncoupled: Increased migration is not an inexorable consequence of EMT.Schaeffer D, Somarelli JA, Hanna G, Palmer GM, Garcia-Blanco MAMol Cell Biol. 2014 Jul 7. pii: MCB.00694-14.2.EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours.Bornachea O, Santos M, Martinez-Cruz AB, Garcia-Escudero R, Duenas M, Costa C, Segrelles C, Lorz C, Buitrago A, Saiz-Ladera C, Agirre X, Grande T, Paradela B, Maraver A, Ariza JM, Prosper F, Serrano M, Sanchez-Cespedes M, Paramio JM.Sci Rep. 2012;2:434. Epub 2012 May 31.3.Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21.Saito Y, Murata-Kamiya N, Hirayama T, Ohba Y, Hatakeyama M.J Exp Med. 2010 Sep 27;207(10):2157-74. Epub 2010 Sep 20.
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