TWIST1 Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a partial recombinant TWIST1.
|Calculated MW||20954 Da|
|Other Names||Twist-related protein 1, Class A basic helix-loop-helix protein 38, bHLHa38, H-twist, TWIST1, BHLHA38, TWIST|
|Target/Specificity||TWIST1 (NP_000465, 100 a.a. ~ 202 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TWIST1 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility hot-spot. Johnatty SE, et al. PLoS Genet, 2010 Jul 8. PMID 20628624.Quantitative assessment of DNA methylation for the detection of cervical neoplasia in liquid-based cytology specimens. Kim JH, et al. Virchows Arch, 2010 Jul. PMID 20496080.PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage. Vichalkovski A, et al. Oncogene, 2010 Jun 17. PMID 20400976.TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214. Yin G, et al. Oncogene, 2010 Jun 17. PMID 20400975.
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