UBE2A Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant UBE2A.
|Calculated MW||17315 Da|
|Other Names||Ubiquitin-conjugating enzyme E2 A, RAD6 homolog A, HR6A, hHR6A, Ubiquitin carrier protein A, Ubiquitin-protein ligase A, UBE2A, RAD6A|
|Target/Specificity||UBE2A (AAH10175, 1 a.a. ~ 152 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||UBE2A Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.
UBE2A, which encodes a ubiquitin-conjugating enzyme, is mutated in a novel X-linked mental retardation syndrome. Nascimento RM, et al. Am J Hum Genet, 2006 Sep. PMID 16909393.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins. Kunapuli P, et al. Oncogene, 2003 May 29. PMID 12776193.Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response. Lyakhovich A, et al. Mol Cell Biol, 2003 Apr. PMID 12640129.RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway. Suzumori N, et al. Proc Natl Acad Sci U S A, 2003 Jan 21. PMID 12525704.
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