UBE4A Antibody (monoclonal) (M08)
Mouse monoclonal antibody raised against a partial recombinant UBE4A.
|Application ||WB, IF, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||122561 Da|
|Other Names||Ubiquitin conjugation factor E4 A, 632-, UBE4A (HGNC:12499)|
|Target/Specificity||UBE4A (NP_004779, 974 a.a. ~ 1073 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||UBE4A Antibody (monoclonal) (M08) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly.
CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53. Shi D, et al. Proc Natl Acad Sci U S A, 2009 Sep 22. PMID 19805293.Autoantibodies against ubiquitination factor E4A (UBE4A) are associated with severity of Crohn's disease. Sakiyama T, et al. Inflamm Bowel Dis, 2008 Mar. PMID 18069675.[Differential expression of USP2, USP14 and UBE4A between ovarian serous cystadenocarcinoma and adjacent normal tissues] Yang Y, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2007 Jun. PMID 17553343.Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.Ufd2, a novel autoantigen in scleroderma, regulates sister chromatid separation. Spinette S, et al. Cell Cycle, 2004 Dec. PMID 15611659.
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