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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   UROS Antibody (monoclonal) (M01)   

UROS Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a full length recombinant UROS.

  • WB - UROS Antibody (monoclonal) (M01) AT4475a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (54.89 KDa) .
  • WB - UROS Antibody (monoclonal) (M01) AT4475a
    UROS monoclonal antibody (M01), clone 1E11-B11 Western Blot analysis of UROS expression in HL-60 ( (Cat # AT4475a )
  • E - UROS Antibody (monoclonal) (M01) AT4475a
    Detection limit for recombinant GST tagged UROS is approximately 1ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10746
Other Accession BC002573
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 1E11-B11
Calculated MW 28628 Da
Additional Information
Gene ID 7390
Other Names Uroporphyrinogen-III synthase, UROIIIS, UROS, Hydroxymethylbilane hydrolyase [cyclizing], Uroporphyrinogen-III cosynthase, UROS
Target/Specificity UROS (AAH02573, 1 a.a. ~ 265 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsUROS Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunther's disease).


Congenital erythropoietic porphyria: a novel uroporphyrinogen III synthase branchpoint mutation reveals underlying wild-type alternatively spliced transcripts. Bishop DF, et al. Blood, 2010 Feb 4. PMID 19965637.Uroporphyrinogen III synthase mutations related to congenital erythropoietic porphyria identify a key helix for protein stability. Fortian A, et al. Biochemistry, 2009 Jan 20. PMID 19099412.Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway. Vargas PD, et al. FEBS J, 2008 Dec. PMID 19021769.Human uroporphyrinogen III synthase: NMR-based mapping of the active site. Cunha L, et al. Proteins, 2008 May 1. PMID 18004775.Identification of mutations in the uroporphyrinogen III cosynthase gene in German patients with congenital erythropoietic porphyria. Wiederholt T, et al. Physiol Res, 2006. PMID 17298225.

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$ 315.00
Cat# AT4475a
(40 western blots)
Availability: 7-10 days
Bulk Size
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